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Faculty of Biology, Chemistry & Earth Sciences

Department of Biochemistry – Prof. Dr. Clemens Steegborn

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Publications

year    2018   2017   2016   2015   2014    all years

2018

You, Weijie; Steegborn, Clemens
Structural Basis of Sirtuin 6 Inhibition by the Hydroxamate Trichostatin A : Implications for Protein Deacylase Drug Development
in Journal of Medicinal Chemistry (2018)
doi:10.1021/acs.jmedchem.8b01455 ...

Pinto, Andrea; El Ali, Zeina; Moniot, Sébastien; Tamborini, Lucia; Steegborn, Clemens; Foresti, Roberta; de Micheli, Carlo
Effects of 3-Bromo-4,5-dihydroisoxazole Derivatives on Nrf2 Activation and Heme Oxygenase-1 Expression
in ChemistryOpen vol. 7 (2018) issue 11. - pp. 858-864
doi:10.1002/open.201800185 ...

Wiggins, Shakarr V.; Steegborn, Clemens; Levin, Lonny R.; Buck, Jochen
Pharmacological modulation of the CO₂/HCO₃⁻/pH-, calcium-, and ATP-sensing soluble adenylyl cyclase
in Pharmacology & Therapeutics vol. 190 (2018) . - pp. 173-186
doi:10.1016/j.pharmthera.2018.05.008 ...

Lachettini, Sara; Trisciuoglio, Daniela; Rotili, Dante; Lucidi, Alessia; Salvati, Erica; Zizza, Pasquale; di Leo, Luca; del Bufalo, Donatella; Ciriolo, Maria Rosa; Leonetti, Carlo; Steegborn, Clemens; Mai, Antonello; Rizzo, Angela; Biroccio, Annamaria
Pharmacological activation of SIRT6 triggers lethal autophagy in human cancer cells
in Cell Death & Disease vol. 9 (2018) issue 10. - pp. 996
doi:10.1038/s41419-018-1065-0 ...

Dai, Han; Sinclair, David A.; Ellis, James L.; Steegborn, Clemens
Sirtuin activators and inhibitors : Promises, achievements, and challenges
in Pharmacology & Therapeutics (2018)
doi:10.1016/j.pharmthera.2018.03.004 ...

Kalbas, Diana; Liebscher, Sandra; Nowak, Theresa; Meleshin, Marat; Pannek, Martin; Popp, Corinna; Alhalabi, Zayan; Bordusa, Frank; Sippl, Wolfgang; Steegborn, Clemens; Schutkowski, Mike
Potent and Selective Inhibitors of Human Sirtuin 5
in Journal of Medicinal Chemistry vol. 61 (2018) issue 6. - pp. 2460-2471
doi:10.1021/acs.jmedchem.7b01648 ...

2017

Pannek, Martin; Simic, Zeljko; Fuszard, Matthew; Meleshin, Marat; Rotili, Dante; Mai, Antonello; Schutkowski, Mike; Steegborn, Clemens
Crystal structures of the mitochondrial deacylase Sirtuin 4 reveal isoform-specific acyl recognition and regulation features
in Nature Communications vol. 8 (2017)
doi:10.1038/s41467-017-01701-2 ...

Rajabi, Nima; Auth, Marina; Troelsen, Kathrin R.; Pannek, Martin; Bhatt, Dhaval; Fontenas, Martin; Hirshey, Matthew D.; Steegborn, Clemens; Madsen, Andreas S.; Olsen, Christian Adam
Mechanism-based Inhibitors of the Human Sirtuin 5 Deacylase : Structure-Activity Relationship, Biostructural, and Kinetic Insight
in Angewandte Chemie International Edition (2017)
doi:10.1002/anie.201709050 ...

Quinti, Luisa; Dayalan Naidu, Sharadha; Träger, Ulrike; Chen, Xiqun; Kegel-Gleason, Kimberly; Llères, David; Connolly, Colúm; Chopra, Vanita; Low, Cho; Moniot, Sébastien; Sapp, Ellen; Tousley, Adelaide R.; Vodicka, Petr; van Kanegan, Michael J.; Kaltenbach, Linda S.; Crawford, Lisa A.; Fuszard, Matthew; Higgins, Maureen; Miller, James R. C.; Farmer, Ruth E.; Potluri, Vijay; Samajdar, Susanta; Meisel, Lisa; Zhang, Ningzhe; Snyder, Andrew; Stein, Ross; Hersch, Steven M.; Ellerby, Lisa M.; Weerapana, Eranthie; Schwarzschild, Michael A.; Steegborn, Clemens; Leavitt, Blair R.; Degterev, Alexei; Tabrizi, Sarah J.; Lo, Donald C.; DiFiglia, Marian; Thompson, Leslie M.; Dinkova-Kostova, Albena T.; Kazantsev, Aleksey G.
KEAP1-modifying small molecule reveals muted NRF2 signaling responses in neural stem cells from Huntington's disease patients
in Proceedings of the National Academy of Sciences of the United States of America vol. 114 (2017) issue 23. - pp. E4676-E4685
doi:10.1073/pnas.1614943114 ...

Graf, Christopher G. F.; Schulz, Christian; Schmalzlein, Marina; Heinlein, Christian; Mönnich, Manuel; Perkams, Lukas; Püttner, Markus; Boos, Irene; Hessefort, Markus; Lombana Sanchez, Jose Nelson; Weyand, Michael; Steegborn, Clemens; Breiden, Bernadette; Ross, Kerstin; Schwarzmann, Günter; Sandhoff, Konrad; Unverzagt, Carlo
Synthetic Glycoforms Reveal Carbohydrate-Dependent Bioactivity of Human Saposin D
in Angewandte Chemie International Edition vol. 56 (2017) issue 19. - pp. 5252-5257
doi:10.1002/anie.201701362 ...

de Oliveira, Rita Machado; Vicente Miranda, Hugo; Francelle, Laetitia; Pinho, Raquel; Szegö, Éva M.; Martinho, Renato; Munari, Francesca; Lázaro, Diana F.; Moniot, Sébastien; Guerreiro, Patrícia; Fonseca-Ornelas, Luis; Marijanovic, Zrinka; Antas, Pedro; Gerhardt, Ellen; Enguita, Francisco Javier; Fauvet, Bruno; Penque, Deborah; Pais, Teresa Faria; Tong, Qiang; Becker, Stefan; Kügler, Sebastian; Lashuel, Hilal Ahmed; Steegborn, Clemens; Zweckstetter, Markus; Outeiro, Tiago F.
Correction: The mechanism of sirtuin 2-mediated exacerbation of alpha-synuclein toxicity in models of Parkinson disease
in PLoS Biology vol. 15 (2017) issue 4
doi:10.1371/journal.pbio.1002601 ...

Li, Jun; Bonkowski, Michael S.; Moniot, Sébastien; Zhang, Dapeng; Hubbard, Basil P.; Ling, Alvin J. Y.; Rajman, Luis A.; Qin, Bo; Lou, Zhenkun; Gorbunova, Vera; Aravind, L.; Steegborn, Clemens; Sinclair, David A.
A conserved NAD+ binding pocket that regulates protein-protein interactions during aging
in Science vol. 355 (2017) issue 6331. - pp. 1312-1317
doi:10.1126/science.aad8242 ...

Moniot, Sébastien; Forgione, Mariantonietta; Lucidi, Alessia; Hailu, Gebremedhin S.; Nebbioso, Angela; Carafa, Vincenzo; Baratta, Francesca; Altucci, Lucia; Giacché, Nicola; Passeri, Daniela; Pellicciari, Roberto; Mai, Antonello; Steegborn, Clemens; Rotili, Dante
Development of 1,2,4-Oxadiazoles as Potent and Selective Inhibitors of the Human Deacetylase Sirtuin 2 : Structure-Activity Relationship, X-ray Crystal Structure, and Anticancer Activity
in Journal of Medicinal Chemistry vol. 60 (2017) issue 6. - pp. 2344-2360
doi:10.1021/acs.jmedchem.6b01609 ...

Sundriyal, Sandeep; Moniot, Sébastien; Mahmud, Zimam; Yao, Shang; di Fruscia, Paolo; Reynolds, Christopher R.; Dexter, David T.; Sternberg, Michael J. E.; Lam, Eric W.-F.; Steegborn, Clemens; Fuchter, Matthew J.
Thienopyrimidinone Based Sirtuin-2 (SIRT2)-Selective Inhibitors Bind in the Ligand Induced Selectivity Pocket
in Journal of Medicinal Chemistry vol. 60 (2017) issue 5. - pp. 1928-1945
doi:10.1021/acs.jmedchem.6b01690 ...

de Oliveira, Rita Machado; Vicente Miranda, Hugo; Francelle, Laetitia; Pinho, Raquel; Szegö, Éva M.; Martinho, Renato; Munari, Francesca; Lázaro, Diana F.; Moniot, Sébastien; Guerreiro, Patrícia; Fonseca, Luis; Marijanovic, Zrinka; Antas, Pedro; Gerhardt, Ellen; Enguita, Francisco Javier; Fauvet, Bruno; Penque, Deborah; Pais, Teresa Faria; Tong, Qiang; Becker, Stefan; Kügler, Sebastian; Lashuel, Hilal Ahmed; Steegborn, Clemens; Zweckstetter, Markus; Outeiro, Tiago F.
The mechanism of sirtuin 2-mediated exacerbation of alpha-synuclein toxicity in models of Parkinson disease
in PLoS Biology vol. 15 (2017) issue 3
doi:10.1371/journal.pbio.2000374 ...

You, Weijie; Rotili, Dante; Li, Tie-Mei; Kambach, Christian; Meleshin, Marat; Schutkowski, Mike; Chua, Katrin F.; Mai, Antonello; Steegborn, Clemens
Structural Basis of Sirtuin 6 Activation by Synthetic Small Molecules
in Angewandte Chemie International Edition vol. 56 (2017) issue 4. - pp. 1007-1011
doi:10.1002/anie.201610082 ...

Schweizer, Ulrich; Towell, Holly; Vit, Allegra; Rodriguez-Ruiz, Alfonso; Steegborn, Clemens
Structural aspects of thyroid hormone binding to proteins and competitive interactions with natural and synthetic compounds
in Molecular and Cellular Endocrinology vol. 458 (2017) . - pp. 57-67
doi:10.1016/j.mce.2017.01.026 ...

2016

Ramos-Espiritu, Lavoisier; Kleinbölting, Silke; Navarrete, Felipe A.; Alvau, Antonio; Visconti, Pablo E.; Valsecchi, Federica; Starkov, Anatoly; Manfredi, Giovanni; Buck, Hannes; Adura, Carolina; Zippin, Jonathan H.; van den Heuvel, Joop; Glickman, J. Fraser; Steegborn, Clemens; Levin, Lonny R.; Buck, Jochen
Discovery of LRE1 as a specific and allosteric inhibitor of soluble adenylyl cyclase
in Nature Chemical Biology vol. 12 (2016) issue 10. - pp. 838-844
doi:10.1038/nchembio.2151 ...

Gertz, Melanie; Steegborn, Clemens
Using mitochondrial sirtuins as drug targets : disease implications and available compounds
in Cellular and Molecular Life Sciences : CMLS vol. 73 (2016) issue 15. - pp. 2871-2896
doi:10.1007/s00018-016-2180-7 ...

Quinti, Luisa; Casale, Malcolm; Moniot, Sébastien; Pais, Teresa Faria; van Kanegan, Michael J.; Kaltenbach, Linda S.; Pallos, Judit; Lim, Ryan G.; Naidu, Sharadha Dayalan; Runne, Heike; Meisel, Lisa; Rauf, Nazifa Abdul; Leyfer, Dmitriy; Maxwell, Michelle M.; Saiah, Eddine; Landers, John E.; Luthi-Carter, Ruth; Abagyan, Ruben; Dinkova-Kostova, Albena T.; Steegborn, Clemens; Marsh, J. Lawrence; Lo, Donald C.; Thompson, Leslie M.; Kazantsev, Aleksey G.
SIRT2- and NRF2-Targeting Thiazole-Containing Compound with Therapeutic Activity in Huntington's Disease Models
in Cell Chemical Biology vol. 23 (2016) issue 7. - pp. 849-861
doi:10.1016/j.chembiol.2016.05.015 ...

Kleinbölting, Silke; Ramos-Espiritu, Lavoisier; Buck, Hannes; Colis, Laureen; van den Heuvel, Joop; Glickman, J. Fraser; Levin, Lonny R.; Buck, Jochen; Steegborn, Clemens
Bithionol potently inhibits human soluble adenylyl cyclase through binding to the allosteric activator site
in The Journal of Biological Chemistry vol. 291 (2016) . - pp. 9776-9784
doi:10.1074/jbc.M115.708255 ...

Valente, Sergio; Mellini, Paolo; Spallotta, Francesco; Carafa, Vincenzo; Nebbioso, Angela; Polletta, Lucia; Carnevale, Ilaria; Saladini, Serena; Trisciuoglio, Daniela; Gabellini, Chiara; Tardugno, Maria; Zwergel, Clemens; Cencioni, Chiara; Atlante, Sandra; Moniot, Sébastien; Steegborn, Clemens; Budriesi, Roberta; Tafani, Marco; del Bufalo, Donatella; Altucci, Lucia; Gaetano, Carlo; Mai, Antonello
1,4-Dihydropyridines Active on the SIRT1/AMPK Pathway Ameliorate Skin Repair and Mitochondrial Function and Exhibit Inhibition of Proliferation in Cancer Cells
in Journal of Medicinal Chemistry vol. 59 (2016) issue 4. - pp. 1471-1491
doi:10.1021/acs.jmedchem.5b01117 ...

Klionsky, Daniel J; Abdelmohsen, Kotb; Abe, Akihisa; Abedin, Md Joynal; Abeliovich, Hagai; Acevedo Arozena, Abraham; Adachi, Hiroaki; Adams, Christopher M; Adams, Peter D; Adeli, Khosrow; Adhihetty, Peter J; Adler, Sharon G; Agam, Galila; Agarwal, Rajesh; Aghi, Manish K; Agnello, Maria; Agostinis, Patrizia; Aguilar, Patricia V; Aguirre-Ghiso, Julio; Airoldi, Edoardo M; Ait-Si-Ali, Slimane; Akematsu, Takahiko; Akporiaye, Emmanuel T; Al-Rubeai, Mohamed; Albaiceta, Guillermo M; Albanese, Chris; Albani, Diego; Albert, Matthew L; Aldudo, Jesus; Algül, Hana; Alirezaei, Mehrdad; Alloza, Iraide; Almasan, Alexandru; Almonte-Beceril, Maylin; Alnemri, Emad S; Alonso, Covadonga; Altan-Bonnet, Nihal; Altieri, Dario C; Alvarez, Silvia; Alvarez-Erviti, Lydia; Alves, Sandro; Amadoro, Giuseppina; Amano, Atsuo; Amantini, Consuelo; Ambrosio, Santiago; Amelio, Ivano; Amer, Amal O; Amessou, Mohamed; Amon, Angelika; An, Zhenyi; Anania, Frank A; Andersen, Stig U; Andley, Usha P; Andreadi, Catherine K; Andrieu-Abadie, Nathalie; Anel, Alberto; Ann, David K; Anoopkumar-Dukie, Shailendra; Antonioli, Manuela; Aoki, Hiroshi; Apostolova, Nadezda; Aquila, Saveria; Aquilano, Katia; Araki, Koichi; Arama, Eli; Aranda, Agustin; Araya, Jun; Arcaro, Alexandre; Arias, Esperanza; Arimoto, Hirokazu; Ariosa, Aileen R; Armstrong, Jane L; Arnould, Thierry; Arsov, Ivica; Asanuma, Katsuhiko; Askanas, Valerie; Asselin, Eric; Atarashi, Ryuichiro; Atherton, Sally S; Atkin, Julie D; Attardi, Laura D; Auberger, Patrick; Auburger, Georg; Aurelian, Laure; Autelli, Riccardo; Avagliano, Laura; Avantaggiati, Maria Laura; Avrahami, Limor; Awale, Suresh; Azad, Neelam; Bachetti, Tiziana; Backer, Jonathan M; Bae, Dong-Hun; Bae, Jae-Sung; Bae, Ok-Nam; Bae, Soo Han; Baehrecke, Eric H; Baek, Seung-Hoon; Baghdiguian, Stephen; Bagniewska-Zadworna, Agnieszka; Bai, Hua; Bai, Jie; Bai, Xue-Yuan; Bailly, Yannick; Balaji, Kithiganahalli Narayanaswamy; Balduini, Walter; Ballabio, Andrea; Balzan, Rena; Banerjee, Rajkumar; Bánhegyi, Gábor; Bao, Haijun; Barbeau, Benoit; Barrachina, Maria D; Barreiro, Esther; Bartel, Bonnie; Bartolomé, Alberto; Bassham, Diane C; Bassi, Maria Teresa; Bast, Robert C; Basu, Alakananda; Batista, Maria Teresa; Batoko, Henri; Battino, Maurizio; Bauckman, Kyle; Baumgarner, Bradley L; Bayer, K Ulrich; Beale, Rupert; Beaulieu, Jean-François; Beck, George R; Becker, Christoph; Beckham, J David; Bédard, Pierre-André; Bednarski, Patrick J; Begley, Thomas J; Behl, Christian; Behrends, Christian; Behrens, Georg Mn; Behrns, Kevin E; Bejarano, Eloy; Belaid, Amine; Belleudi, Francesca; Bénard, Giovanni; Berchem, Guy; Bergamaschi, Daniele; Bergami, Matteo; Berkhout, Ben; Berliocchi, Laura; Bernard, Amélie; Bernard, Monique; Bernassola, Francesca; Bertolotti, Anne; Bess, Amanda S; Besteiro, Sébastien; Bettuzzi, Saverio; Bhalla, Savita; Bhattacharyya, Shalmoli; Bhutia, Sujit K; Biagosch, Caroline; Bianchi, Michele Wolfe; Biard-Piechaczyk, Martine; Billes, Viktor; Bincoletto, Claudia; Bingol, Baris; Bird, Sara W; Bitoun, Marc; Bjedov, Ivana; Blackstone, Craig; Blanc, Lionel; Blanco, Guillermo A; Blomhoff, Heidi Kiil; Boada-Romero, Emilio; Böckler, Stefan; Boes, Marianne; Boesze-Battaglia, Kathleen; Boise, Lawrence H; Bolino, Alessandra; Boman, Andrea; Bonaldo, Paolo; Bordi, Matteo; Bosch, Jürgen; Botana, Luis M; Botti, Joelle; Bou, German; Bouché, Marina; Bouchecareilh, Marion; Boucher, Marie-Josée; Boulton, Michael E; Bouret, Sebastien G; Boya, Patricia; Boyer-Guittaut, Michaël; Bozhkov, Peter V; Brady, Nathan; Braga, Vania Mm; Brancolini, Claudio; Braus, Gerhard H.; Bravo-San Pedro, José M; Brennan, Lisa A; Bresnick, Emery H; Brest, Patrick; Bridges, Dave; Bringer, Marie-Agnès; Brini, Marisa; Brito, Glauber C; Brodin, Bertha; Brookes, Paul S; Brown, Eric J; Brown, Karen; Broxmeyer, Hal E; Bruhat, Alain; Brum, Patricia Chakur; Brumell, John H; Brunetti-Pierri, Nicola; Bryson-Richardson, Robert J; Buch, Shilpa; Buchan, Alastair M; Budak, Hikmet; Bulavin, Dmitry V; Bultman, Scott J; Bultynck, Geert; Bumbasirevic, Vladimir; Burelle, Yan; Burke, Robert E; Burmeister, Margit; Bütikofer, Peter; Caberlotto, Laura; Cadwell, Ken; Cahova, Monika; Cai, Dongsheng; Cai, Jingjing; Cai, Qian; Calatayud, Sara; Camougrand, Nadine; Campanella, Michelangelo; Campbell, Grant R; Campbell, Matthew; Campello, Silvia; Candau, Robin; Caniggia, Isabella; Cantoni, Lavinia; Cao, Lizhi; Caplan, Allan B; Caraglia, Michele; Cardinali, Claudio; Cardoso, Sandra Morais; Carew, Jennifer S; Carleton, Laura A; Carlin, Cathleen R; Carloni, Silvia; Carlsson, Sven R; Carmona-Gutierrez, Didac; Carneiro, Leticia Am; Carnevali, Oliana; Carra, Serena; Carrier, Alice; Carroll, Bernadette; Casas, Caty; Casas, Josefina; Cassinelli, Giuliana; Castets, Perrine; Castro-Obregon, Susana; Cavallini, Gabriella; Ceccherini, Isabella; Cecconi, Francesco; Cederbaum, Arthur I; Ceña, Valentín; Cenci, Simone; Cerella, Claudia; Cervia, Davide; Cetrullo, Silvia; Chaachouay, Hassan; Chae, Han-Jung; Chagin, Andrei S; Chai, Chee-Yin; Chakrabarti, Gopal; Chamilos, Georgios; Chan, Edmond Yw; Chan, Matthew Tv; Chandra, Dhyan; Chandra, Pallavi; Chang, Chih-Peng; Chang, Raymond Chuen-Chung; Chang, Ta Yuan; Chatham, John C; Chatterjee, Saurabh; Chauhan, Santosh; Che, Yongsheng; Cheetham, Michael E; Cheluvappa, Rajkumar; Chen, Chun-Jung; Chen, Gang; Chen, Guang-Chao; Chen, Guoqiang; Chen, Hongzhuan; Chen, Jeff W; Chen, Jian-Kang; Chen, Min; Chen, Mingzhou; Chen, Peiwen; Chen, Qi; Chen, Quan; Chen, Shang-Der; Chen, Si; Chen, Steve S-L; Chen, Wei; Chen, Wei-Jung; Chen, Wen Qiang; Chen, Wenli; Chen, Xiangmei; Chen, Yau-Hung; Chen, Ye-Guang; Chen, Yin; Chen, Yingyu; Chen, Yongshun; Chen, Yu-Jen; Chen, Yue-Qin; Chen, Yujie; Chen, Zhen; Chen, Zhong; Cheng, Alan; Cheng, Christopher Hk; Cheng, Hua; Cheong, Heesun; Cherry, Sara; Chesney, Jason; Cheung, Chun Hei Antonio; Chevet, Eric; Chi, Hsiang Cheng; Chi, Sung-Gil; Chiacchiera, Fulvio; Chiang, Hui-Ling; Chiarelli, Roberto; Chiariello, Mario; Chieppa, Marcello; Chin, Lih-Shen; Chiong, Mario; Chiu, Gigi Nc; Cho, Dong-Hyung; Cho, Ssang-Goo; Cho, William C; Cho, Yong-Yeon; Cho, Young-Seok; Choi, Augustine Mk; Choi, Eui-Ju; Choi, Eun-Kyoung; Choi, Jayoung; Choi, Mary E; Choi, Seung-Il; Chou, Tsui-Fen; Chouaib, Salem; Choubey, Divaker; Choubey, Vinay; Chow, Kuan-Chih; Chowdhury, Kamal; Chu, Charleen T; Chuang, Tsung-Hsien; Chun, Taehoon; Chung, Hyewon; Chung, Taijoon; Chung, Yuen-Li; Chwae, Yong-Joon; Cianfanelli, Valentina; Ciarcia, Roberto; Ciechomska, Iwona A; Ciriolo, Maria Rosa; Cirone, Mara; Claerhout, Sofie; Clague, Michael J; Clària, Joan; Clarke, Peter Gh; Clarke, Robert; Clementi, Emilio; Cleyrat, Cédric; Cnop, Miriam; Coccia, Eliana M; Cocco, Tiziana; Codogno, Patrice; Coers, Jörn; Cohen, Ezra Ew; Colecchia, David; Coletto, Luisa; Coll, Núria S; Colucci-Guyon, Emma; Comincini, Sergio; Condello, Maria; Cook, Katherine L; Coombs, Graham H; Cooper, Cynthia D; Cooper, J Mark; Coppens, Isabelle; Corasaniti, Maria Tiziana; Corazzari, Marco; Corbalan, Ramon; Corcelle-Termeau, Elisabeth; Cordero, Mario D; Corral-Ramos, Cristina; Corti, Olga; Cossarizza, Andrea; Costelli, Paola; Costes, Safia; Cotman, Susan L; Coto-Montes, Ana; Cottet, Sandra; Couve, Eduardo; Covey, Lori R; Cowart, L Ashley; Cox, Jeffery S; Coxon, Fraser P; Coyne, Carolyn B; Cragg, Mark S; Craven, Rolf J; Crepaldi, Tiziana; Crespo, Jose L; Criollo, Alfredo; Crippa, Valeria; Cruz, Maria Teresa; Cuervo, Ana Maria; Cuezva, Jose M; Cui, Taixing; Cutillas, Pedro R; Czaja, Mark J; Czyzyk-Krzeska, Maria F; Dagda, Ruben K; Dahmen, Uta; Dai, Chunsun; Dai, Wenjie; Dai, Yun; Dalby, Kevin N; Dalla Valle, Luisa; Dalmasso, Guillaume; D'Amelio, Marcello; Damme, Markus; Darfeuille-Michaud, Arlette; Dargemont, Catherine; Darley-Usmar, Victor M; Dasarathy, Srinivasan; Dasgupta, Biplab; Dash, Srikanta; Dass, Crispin R; Davey, Hazel Marie; Davids, Lester M; Dávila, David; Davis, Roger J; Dawson, Ted M; Dawson, Valina L; Daza, Paula; de Belleroche, Jackie; de Figueiredo, Paul; de Figueiredo, Regina Celia Bressan Queiroz; de la Fuente, José; De Martino, Luisa; De Matteis, Antonella; De Meyer, Guido Ry; De Milito, Angelo; De Santi, Mauro; de Souza, Wanderley; De Tata, Vincenzo; De Zio, Daniela; Debnath, Jayanta; Dechant, Reinhard; Decuypere, Jean-Paul; Deegan, Shane; Dehay, Benjamin; Del Bello, Barbara; Del Re, Dominic P; Delage-Mourroux, Régis; Delbridge, Lea Md; Deldicque, Louise; Delorme-Axford, Elizabeth; Deng, Yizhen; Dengjel, Joern; Denizot, Melanie; Dent, Paul; Der, Channing J; Deretic, Vojo; Derrien, Benoît; Deutsch, Eric; Devarenne, Timothy P; Devenish, Rodney J; Di Bartolomeo, Sabrina; Di Daniele, Nicola; Di Domenico, Fabio; Di Nardo, Alessia; Di Paola, Simone; Di Pietro, Antonio; Di Renzo, Livia; DiAntonio, Aaron; Díaz-Araya, Guillermo; Díaz-Laviada, Ines; Diaz-Meco, Maria T; Diaz-Nido, Javier; Dickey, Chad A; Dickson, Robert C; Diederich, Marc; Digard, Paul; Dikic, Ivan; Dinesh-Kumar, Savithrama P; Ding, Chan; Ding, Wen-Xing; Ding, Zufeng; Dini, Luciana; Distler, Jörg Hw; Diwan, Abhinav; Djavaheri-Mergny, Mojgan; Dmytruk, Kostyantyn; Dobson, Renwick Cj; Doetsch, Volker; Dokladny, Karol; Dokudovskaya, Svetlana; Donadelli, Massimo; Dong, X Charlie; Dong, Xiaonan; Dong, Zheng; Donohue, Terrence M; Doran, Kelly S; D'Orazi, Gabriella; Dorn, Gerald W; Dosenko, Victor; Dridi, Sami; Drucker, Liat; Du, Jie; Du, Li-Lin; Du, Lihuan; du Toit, André; Dua, Priyamvada; Duan, Lei; Duann, Pu; Dubey, Vikash Kumar; Duchen, Michael R; Duchosal, Michel A; Duez, Helene; Dugail, Isabelle; Dumit, Verónica I; Duncan, Mara C; Dunlop, Elaine A; Dunn, William A; Dupont, Nicolas; Dupuis, Luc; Durán, Raúl V; Durcan, Thomas M; Duvezin-Caubet, Stéphane; Duvvuri, Umamaheswar; Eapen, Vinay; Ebrahimi-Fakhari, Darius; Echard, Arnaud; Eckhart, Leopold; Edelstein, Charles L; Edinger, Aimee L; Eichinger, Ludwig; Eisenberg, Tobias; Eisenberg-Lerner, Avital; Eissa, N Tony; El-Deiry, Wafik S; El-Khoury, Victoria; Elazar, Zvulun; Eldar-Finkelman, Hagit; Elliott, Chris Jh; Emanuele, Enzo; Emmenegger, Urban; Engedal, Nikolai; Engelbrecht, Anna-Mart; Engelender, Simone; Enserink, Jorrit M; Erdmann, Ralf; Erenpreisa, Jekaterina; Eri, Rajaraman; Eriksen, Jason L; Erman, Andreja; Escalante, Ricardo; Eskelinen, Eeva-Liisa; Espert, Lucile; Esteban-Martínez, Lorena; Evans, Thomas J; Fabri, Mario; Fabrias, Gemma; Fabrizi, Cinzia; Facchiano, Antonio; Færgeman, Nils J; Faggioni, Alberto; Fairlie, W Douglas; Fan, Chunhai; Fan, Daping; Fan, Jie; Fang, Shengyun; Fanto, Manolis; Fanzani, Alessandro; Farkas, Thomas; Faure, Mathias; Favier, Francois B; Fearnhead, Howard; Federici, Massimo; Fei, Erkang; Felizardo, Tania C; Feng, Hua; Feng, Yibin; Feng, Yuchen; Ferguson, Thomas A; Fernández, Álvaro F; Fernandez-Barrena, Maite G; Fernandez-Checa, Jose C; Fernández-López, Arsenio; Fernandez-Zapico, Martin E; Feron, Olivier; Ferraro, Elisabetta; Ferreira-Halder, Carmen Veríssima; Fesus, Laszlo; Feuer, Ralph; Fiesel, Fabienne C; Filippi-Chiela, Eduardo C; Filomeni, Giuseppe; Fimia, Gian Maria; Fingert, John H; Finkbeiner, Steven; Finkel, Toren; Fiorito, Filomena; Fisher, Paul B; Flajolet, Marc; Flamigni, Flavio; Florey, Oliver; Florio, Salvatore; Floto, R Andres; Folini, Marco; Follo, Carlo; Fon, Edward A; Fornai, Francesco; Fortunato, Franco; Fraldi, Alessandro; Franco, Rodrigo; Francois, Arnaud; François, Aurélie; Frankel, Lisa B; Fraser, Iain Dc; Frey, Norbert; Freyssenet, Damien G; Frezza, Christian; Friedman, Scott L; Frigo, Daniel E; Fu, Dongxu; Fuentes, José M; Fueyo, Juan; Fujitani, Yoshio; Fujiwara, Yuuki; Fujiya, Mikihiro; Fukuda, Mitsunori; Fulda, Simone; Fusco, Carmela; Gabryel, Bozena; Gaestel, Matthias; Gailly, Philippe; Gajewska, Malgorzata; Galadari, Sehamuddin; Galili, Gad; Galindo, Inmaculada; Galindo, Maria F; Galliciotti, Giovanna; Galluzzi, Lorenzo; Galluzzi, Luca; Galy, Vincent; Gammoh, Noor; Gandy, Sam; Ganesan, Anand K; Ganesan, Swamynathan; Ganley, Ian G; Gannagé, Monique; Gao, Fen-Biao; Gao, Feng; Gao, Jian-Xin; García Nannig, Lorena; García Véscovi, Eleonora; Garcia-Macía, Marina; Garcia-Ruiz, Carmen; Garg, Abhishek D; Garg, Pramod Kumar; Gargini, Ricardo; Gassen, Nils Christian; Gatica, Damián; Gatti, Evelina; Gavard, Julie; Gavathiotis, Evripidis; Ge, Liang; Ge, Pengfei; Ge, Shengfang; Gean, Po-Wu; Gelmetti, Vania; Genazzani, Armando A; Geng, Jiefei; Genschik, Pascal; Gerner, Lisa; Gestwicki, Jason E; Gewirtz, David A; Ghavami, Saeid; Ghigo, Eric; Ghosh, Debabrata; Giammarioli, Anna Maria; Giampieri, Francesca; Giampietri, Claudia; Giatromanolaki, Alexandra; Gibbings, Derrick J; Gibellini, Lara; Gibson, Spencer B; Ginet, Vanessa; Giordano, Antonio; Giorgini, Flaviano; Giovannetti, Elisa; Girardin, Stephen E; Gispert, Suzana; Giuliano, Sandy; Gladson, Candece L; Glavic, Alvaro; Gleave, Martin; Godefroy, Nelly; Gogal, Robert M; Gokulan, Kuppan; Goldman, Gustavo H; Goletti, Delia; Goligorsky, Michael S; Gomes, Aldrin V; Gomes, Ligia C; Gomez, Hernando; Gomez-Manzano, Candelaria; Gómez-Sánchez, Rubén; Gonçalves, Dawit Ap; Goncu, Ebru; Gong, Qingqiu; Gongora, Céline; Gonzalez, Carlos B; Gonzalez-Alegre, Pedro; Gonzalez-Cabo, Pilar; González-Polo, Rosa Ana; Goping, Ing Swie; Gorbea, Carlos; Gorbunov, Nikolai V; Goring, Daphne R; Gorman, Adrienne M; Gorski, Sharon M; Goruppi, Sandro; Goto-Yamada, Shino; Gotor, Cecilia; Gottlieb, Roberta A; Gozes, Illana; Gozuacik, Devrim; Graba, Yacine; Graef, Martin; Granato, Giovanna E; Grant, Gary Dean; Grant, Steven; Gravina, Giovanni Luca; Green, Douglas R; Greenhough, Alexander; Greenwood, Michael T; Grimaldi, Benedetto; Gros, Frédéric; Grose, Charles; Groulx, Jean-Francois; Gruber, Florian; Grumati, Paolo; Grune, Tilman; Guan, Jun-Lin; Guan, Kun-Liang; Guerra, Barbara; Guillen, Carlos; Gulshan, Kailash; Gunst, Jan; Guo, Chuanyong; Guo, Lei; Guo, Ming; Guo, Wenjie; Guo, Xu-Guang; Gust, Andrea A; Gustafsson, Åsa B; Gutierrez, Elaine; Gutierrez, Maximiliano G; Gwak, Ho-Shin; Haas, Albert; Haber, James E; Hadano, Shinji; Hagedorn, Monica; Hahn, David R; Halayko, Andrew J; Hamacher-Brady, Anne; Hamada, Kozo; Hamai, Ahmed; Hamann, Andrea; Hamasaki, Maho; Hamer, Isabelle; Hamid, Qutayba; Hammond, Ester M; Han, Feng; Han, Weidong; Handa, James T; Hanover, John A; Hansen, Malene; Harada, Masaru; Harhaji-Trajkovic, Ljubica; Harper, J Wade; Harrath, Abdel Halim; Harris, Adrian L; Harris, James; Hasler, Udo; Hasselblatt, Peter; Hasui, Kazuhisa; Hawley, Robert G; Hawley, Teresa S; He, Congcong; He, Cynthia Y; He, Fengtian; He, Gu; He, Rong-Rong; He, Xian-Hui; He, You-Wen; He, Yu-Ying; Heath, Joan K; Hébert, Marie-Josée; Heinzen, Robert A; Helgason, Gudmundur Vignir; Hensel, Michael; Henske, Elizabeth P; Her, Chengtao; Herman, Paul K; Hernández, Agustín; Hernandez, Carlos; Hernández-Tiedra, Sonia; Hetz, Claudio; Hiesinger, P Robin; Higaki, Katsumi; Hilfiker, Sabine; Hill, Bradford G; Hill, Joseph A; Hill, William D; Hino, Keisuke; Hofius, Daniel; Hofman, Paul; Höglinger, Günter U; Höhfeld, Jörg; Holz, Marina K; Hong, Yonggeun; Hood, David A; Hoozemans, Jeroen Jm; Hoppe, Thorsten; Hsu, Chin; Hsu, Chin-Yuan; Hsu, Li-Chung; Hu, Dong; Hu, Guochang; Hu, Hong-Ming; Hu, Hongbo; Hu, Ming Chang; Hu, Yu-Chen; Hu, Zhuo-Wei; Hua, Fang; Hua, Ya; Huang, Canhua; Huang, Huey-Lan; Huang, Kuo-How; Huang, Kuo-Yang; Huang, Shile; Huang, Shiqian; Huang, Wei-Pang; Huang, Yi-Ran; Huang, Yong; Huang, Yunfei; Huber, Tobias B; Huebbe, Patricia; Huh, Won-Ki; Hulmi, Juha J; Hur, Gang Min; Hurley, James H; Husak, Zvenyslava; Hussain, Sabah Na; Hussain, Salik; Hwang, Jung Jin; Hwang, Seungmin; Hwang, Thomas Is; Ichihara, Atsuhiro; Imai, Yuzuru; Imbriano, Carol; Inomata, Megumi; Into, Takeshi; Iovane, Valentina; Iovanna, Juan L; Iozzo, Renato V; Ip, Nancy Y; Irazoqui, Javier E; Iribarren, Pablo; Isaka, Yoshitaka; Isakovic, Aleksandra J; Ischiropoulos, Harry; Isenberg, Jeffrey S; Ishaq, Mohammad; Ishida, Hiroyuki; Ishii, Isao; Ishmael, Jane E; Isidoro, Ciro; Isobe, Ken-Ichi; Isono, Erika; Issazadeh-Navikas, Shohreh; Itahana, Koji; Itakura, Eisuke; Ivanov, Andrei I; Iyer, Anand Krishnan V; Izquierdo, José M; Izumi, Yotaro; Izzo, Valentina; Jäättelä, Marja; Jaber, Nadia; Jackson, Daniel John; Jackson, William T; Jacob, Tony George; Jacques, Thomas S; Jagannath, Chinnaswamy; Jain, Ashish; Jana, Nihar Ranjan; Jang, Byoung Kuk; Jani, Alkesh; Janji, Bassam; Jannig, Paulo Roberto; Jansson, Patric J; Jean, Steve; Jendrach, Marina; Jeon, Ju-Hong; Jessen, Niels; Jeung, Eui-Bae; Jia, Kailiang; Jia, Lijun; Jiang, Hong; Jiang, Hongchi; Jiang, Liwen; Jiang, Teng; Jiang, Xiaoyan; Jiang, Xuejun; Jiang, Xuejun; Jiang, Ying; Jiang, Yongjun; Jiménez, Alberto; Jin, Cheng; Jin, Hongchuan; Jin, Lei; Jin, Meiyan; Jin, Shengkan; Jinwal, Umesh Kumar; Jo, Eun-Kyeong; Johansen, Terje; Johnson, Daniel E; Johnson, Gail Vw; Johnson, James D; Jonasch, Eric; Jones, Chris; Joosten, Leo Ab; Jordan, Joaquin; Joseph, Anna-Maria; Joseph, Bertrand; Joubert, Annie M; Ju, Dianwen; Ju, Jingfang; Juan, Hsueh-Fen; Juenemann, Katrin; Juhász, Gábor; Jung, Hye Seung; Jung, Jae U; Jung, Yong-Keun; Jungbluth, Heinz; Justice, Matthew J; Jutten, Barry; Kaakoush, Nadeem O; Kaarniranta, Kai; Kaasik, Allen; Kabuta, Tomohiro; Kaeffer, Bertrand; Kågedal, Katarina; Kahana, Alon; Kajimura, Shingo; Kakhlon, Or; Kalia, Manjula; Kalvakolanu, Dhan V; Kamada, Yoshiaki; Kambas, Konstantinos; Kaminskyy, Vitaliy O; Kampinga, Harm H; Kandouz, Mustapha; Kang, Chanhee; Kang, Rui; Kang, Tae-Cheon; Kanki, Tomotake; Kanneganti, Thirumala-Devi; Kanno, Haruo; Kanthasamy, Anumantha G; Kantorow, Marc; Kaparakis-Liaskos, Maria; Kapuy, Orsolya; Karantza, Vassiliki; Karim, Md Razaul; Karmakar, Parimal; Kaser, Arthur; Kaushik, Susmita; Kawula, Thomas; Kaynar, A Murat; Ke, Po-Yuan; Ke, Zun-Ji; Kehrl, John H; Keller, Kate E; Kemper, Jongsook Kim; Kenworthy, Anne K; Kepp, Oliver; Kern, Andreas; Kesari, Santosh; Kessel, David; Ketteler, Robin; Kettelhut, Isis do Carmo; Khambu, Bilon; Khan, Muzamil Majid; Khandelwal, Vinoth Km; Khare, Sangeeta; Kiang, Juliann G; Kiger, Amy A; Kihara, Akio; Kim, Arianna L; Kim, Cheol Hyeon; Kim, Deok Ryong; Kim, Do-Hyung; Kim, Eung Kweon; Kim, Hye Young; Kim, Hyung-Ryong; Kim, Jae-Sung; Kim, Jeong Hun; Kim, Jin Cheon; Kim, Jin Hyoung; Kim, Kwang Woon; Kim, Michael D; Kim, Moon-Moo; Kim, Peter K; Kim, Seong Who; Kim, Soo-Youl; Kim, Yong-Sun; Kim, Yonghyun; Kimchi, Adi; Kimmelman, Alec C; Kimura, Tomonori; King, Jason S; Kirkegaard, Karla; Kirkin, Vladimir; Kirshenbaum, Lorrie A; Kishi, Shuji; Kitajima, Yasuo; Kitamoto, Katsuhiko; Kitaoka, Yasushi; Kitazato, Kaio; Kley, Rudolf A; Klimecki, Walter T; Klinkenberg, Michael; Klucken, Jochen; Knævelsrud, Helene; Knecht, Erwin; Knuppertz, Laura; Ko, Jiunn-Liang; Kobayashi, Satoru; Koch, Jan C; Koechlin-Ramonatxo, Christelle; Koenig, Ulrich; Koh, Young Ho; Köhler, Katja; Kohlwein, Sepp D; Koike, Masato; Komatsu, Masaaki; Kominami, Eiki; Kong, Dexin; Kong, Hee Jeong; Konstantakou, Eumorphia G; Kopp, Benjamin T; Korcsmaros, Tamas; Korhonen, Laura; Korolchuk, Viktor I; Koshkina, Nadya V; Kou, Yanjun; Koukourakis, Michael I; Koumenis, Constantinos; Kovács, Attila L; Kovács, Tibor; Kovacs, Werner J; Koya, Daisuke; Kraft, Claudine; Krainc, Dimitri; Kramer, Helmut; Kravic-Stevovic, Tamara; Krek, Wilhelm; Kretz-Remy, Carole; Krick, Roswitha; Krishnamurthy, Malathi; Kriston-Vizi, Janos; Kroemer, Guido; Kruer, Michael C; Kruger, Rejko; Ktistakis, Nicholas T; Kuchitsu, Kazuyuki; Kuhn, Christian; Kumar, Addanki Pratap; Kumar, Anuj; Kumar, Ashok; Kumar, Deepak; Kumar, Dhiraj; Kumar, Rakesh; Kumar, Sharad; Kundu, Mondira; Kung, Hsing-Jien; Kuno, Atsushi; Kuo, Sheng-Han; Kuret, Jeff; Kurz, Tino; Kwok, Terry; Kwon, Taeg Kyu; Kwon, Yong Tae; Kyrmizi, Irene; La Spada, Albert R; Lafont, Frank; Lahm, Tim; Lakkaraju, Aparna; Lam, Truong; Lamark, Trond; Lancel, Steve; Landowski, Terry H; Lane, Darius Jr; Lane, Jon D; Lanzi, Cinzia; Lapaquette, Pierre; Lapierre, Louis R; Laporte, Jocelyn; Laukkarinen, Johanna; Laurie, Gordon W; Lavandero, Sergio; Lavie, Lena; LaVoie, Matthew J; Law, Betty Yuen Kwan; Law, Helen Ka-Wai; Law, Kelsey B; Layfield, Robert; Lazo, Pedro A; Le Cam, Laurent; Le Roch, Karine G; Le Stunff, Hervé; Leardkamolkarn, Vijittra; Lecuit, Marc; Lee, Byung-Hoon; 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Lim, Hyunjung Jade; Lim, Kah-Leong; Lim, Kyu; Lima, Raquel T; Lin, Chang-Shen; Lin, Chiou-Feng; Lin, Fang; Lin, Fangming; Lin, Fu-Cheng; Lin, Kui; Lin, Kwang-Huei; Lin, Pei-Hui; Lin, Tianwei; Lin, Wan-Wan; Lin, Yee-Shin; Lin, Yong; Linden, Rafael; Lindholm, Dan; Lindqvist, Lisa M; Lingor, Paul; Linkermann, Andreas; Liotta, Lance A; Lipinski, Marta M; Lira, Vitor A; Lisanti, Michael P; Liton, Paloma B; Liu, Bo; Liu, Chong; Liu, Chun-Feng; Liu, Fei; Liu, Hung-Jen; Liu, Jianxun; Liu, Jing-Jing; Liu, Jing-Lan; Liu, Ke; Liu, Leyuan; Liu, Liang; Liu, Quentin; Liu, Rong-Yu; Liu, Shiming; Liu, Shuwen; Liu, Wei; Liu, Xian-De; Liu, Xiangguo; Liu, Xiao-Hong; Liu, Xinfeng; Liu, Xu; Liu, Xueqin; Liu, Yang; Liu, Yule; Liu, Zexian; Liu, Zhe; Liuzzi, Juan P; Lizard, Gérard; Ljujic, Mila; Lodhi, Irfan J; Logue, Susan E; Lokeshwar, Bal L; Long, Yun Chau; Lonial, Sagar; Loos, Benjamin; López-Otín, Carlos; López-Vicario, Cristina; Lorente, Mar; Lorenzi, Philip L; Lõrincz, Péter; Los, Marek; Lotze, Michael T; Lovat, Penny E; Lu, Binfeng; Lu, Bo; Lu, Jiahong; Lu, Qing; Lu, She-Min; Lu, Shuyan; Lu, Yingying; Luciano, Frédéric; Luckhart, Shirley; Lucocq, John Milton; Ludovico, Paula; Lugea, Aurelia; Lukacs, Nicholas W; Lum, Julian J; Lund, Anders H; Luo, Honglin; Luo, Jia; Luo, Shouqing; Luparello, Claudio; Lyons, Timothy; Ma, Jianjie; Ma, Yi; Ma, Yong; Ma, Zhenyi; Machado, Juliano; Machado-Santelli, Glaucia M; Macian, Fernando; MacIntosh, Gustavo C; MacKeigan, Jeffrey P; Macleod, Kay F; MacMicking, John D; MacMillan-Crow, Lee Ann; Madeo, Frank; Madesh, Muniswamy; Madrigal-Matute, Julio; Maeda, Akiko; Maeda, Tatsuya; Maegawa, Gustavo; Maellaro, Emilia; Maes, Hannelore; Magariños, Marta; Maiese, Kenneth; Maiti, Tapas K; Maiuri, Luigi; Maiuri, Maria Chiara; Maki, Carl G; Malli, Roland; Malorni, Walter; Maloyan, Alina; Mami-Chouaib, Fathia; Man, Na; Mancias, Joseph D; Mandelkow, Eva-Maria; Mandell, Michael A; Manfredi, Angelo A; Manié, Serge N; Manzoni, Claudia; Mao, Kai; Mao, Zixu; Mao, Zong-Wan; 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Guidelines for the use and interpretation of assays for monitoring autophagy. (3rd edition)
in Autophagy vol. 12 (2016) issue 1. - pp. 1-222
doi:10.1080/15548627.2015.1100356 ...

Schuster, Sabine; Roessler, Claudia; Meleshin, Marat; Zimmermann, Philipp; Simic, Zeljko; Kambach, Christian; Schiene-Fischer, Cordelia; Steegborn, Clemens; Hottiger, Michael O.; Schutkowski, Mike
A continuous sirtuin activity assay without any coupling to enzymatic or chemical reactions
in Scientific Reports vol. 6 (2016) . - pp. 22643
doi:10.1038/srep22643 ...

Suenkel, Benjamin; Steegborn, Clemens
Recombinant Preparation, Biochemical Analysis, and Structure Determination of Sirtuin Family Histone/Protein Deacylases
in Methods in Enzymology vol. 573 (2016) . - pp. 183-208
doi:10.1016/bs.mie.2015.12.004 ...

2015

Simic, Zeljko; Weiwad, Matthias; Schierhorn, Angelika; Steegborn, Clemens; Schutkowski, Mike
The ɛ-Amino Group of Protein Lysine Residues Is Highly Susceptible to Nonenzymatic Acylation by Several Physiological Acyl-CoA Thioesters
in ChemBioChem vol. 16 (2015) issue 16. - pp. 2337-2347
doi:10.1002/cbic.201500364 ...

Schweizer, Ulrich; Steegborn, Clemens
New insights into the structure and mechanism of iodothyronine deiodinases
in Journal of Molecular Endocrinology vol. 56 (2015) issue 2. - pp. R37-R52
doi:10.1530/JME-15-0156 ...

Schweizer, Ulrich; Steegborn, Clemens
Thyroid hormones - From Crystal Packing to Activity to Reactivity
in Angewandte Chemie International Edition (2015)
doi:10.1002/anie.201506919 ...

Roessler, Claudia; Tüting, Christian; Meleshin, Marat; Steegborn, Clemens; Schutkowski, Mike
A Novel Continuous Assay for the Deacylase Sirtuin 5 and Other Deacetylases
in Journal of Medicinal Chemistry (2015)
doi:10.1021/acs.jmedchem.5b00293 ...

Banerjee, Arka; Adolph, Ramona S.; Gopalakrishnapai, Jayashree; Kleinbölting, Silke; Emmerich, Christiane; Steegborn, Clemens; Visweswariah, Sandhya S.
A Universal Stress Protein (USP) in Mycobacteria binds cAMP.
in The Journal of Biological Chemistry (2015)
doi:10.1074/jbc.M115.644856 ...

Polletta, Lucia; Vernucci, Enza; Carnevale, Ilaria; Arcangeli, Tania; Rotili, Dante; Palmerio, Silvia; Steegborn, Clemens; Nowak, Theresa; Schutkowski, Mike; Pellegrini, Laura; Sansone, Luigi; Villanova, Lidia; Runci, Alessandra; Pucci, Bruna; Morgante, Emanuela; Fini, Massimo; Mai, Antonello; Russo, Matteo A.; Tafani, Marco
SIRT5 regulation of ammonia-induced autophagy and mitophagy.
in Autophagy vol. 11 (2015) issue 2. - pp. 253-270
doi:10.1080/15548627.2015.1009778 ...

di Fruscia, Paolo; Zacharioudakis, Emmanouil; Liu, Chang; Moniot, Sébastien; Laohasinnarong, Sasiwan; Khongkow, Mattaka; Harrison, Ian F.; Koltsida, Konstantina; Reynolds, Christopher R.; Schmidtkunz, Karin; Jung, Manfred; Chapman, Kathryn L.; Steegborn, Clemens; Dexter, David T.; Sternberg, Michael J. E.; Lam, Eric W.-F.; Fuchter, Matthew J.
The discovery of a highly selective 5,6,7,8-tetrahydrobenzo[4,5]thieno[2,3-d]pyrimidin-4(3H)-one SIRT2 inhibitor that is neuroprotective in an in vitro Parkinson's disease model.
in ChemMedChem vol. 10 (2015) issue 1. - pp. 69-82
doi:10.1002/cmdc.201402431 ...

Fränzel, Benjamin; Fischer, Frank; Steegborn, Clemens; Wolters, Dirk
Proteinase K improves quantitative acylation studies
in Proteomics vol. 15 (2015) issue 1. - pp. 44-47
doi:10.1002/pmic.201400015 ...

Rumpf, Tobias; Schiedel, Matthias; Karaman, Berin; Roessler, Claudia; North, Brian J.; Lehotzky, Attila; Oláh, Judit; Ladwein, Kathrin I.; Schmidtkunz, Karin; Gajer, Markus; Pannek, Martin; Steegborn, Clemens; Sinclair, David A.; Gerhardt, Stefan; Ovádi, Judit; Schutkowski, Mike; Sippl, Wolfgang; Einsle, Oliver; Jung, Manfred
Selective Sirt2 inhibition by ligand-induced rearrangement of the active site.
in Nature Communications vol. 6 (2015) . - pp. 6263
doi:10.1038/ncomms7263 ...

Chen, Xiqun; Wales, Pauline; Quinti, Luisa; Zuo, Fuxing; Moniot, Sébastien; Herisson, Fanny; Rauf, Nazifa Abdul; Wang, Hua; Silverman, Richard B.; Ayata, Cenk; Maxwell, Michelle M.; Steegborn, Clemens; Schwarzschild, Michael A.; Outeiro, Tiago F.; Kazantsev, Aleksey G.
The sirtuin-2 inhibitor AK7 is neuroprotective in models of Parkinson's disease but not amyotrophic lateral sclerosis and cerebral ischemia.
in PLoS One vol. 10 (2015) issue 1. - pp. e0116919
doi:10.1371/journal.pone.0116919 ...

2014

Steegborn, Clemens
Structure, mechanism, and regulation of soluble adenylyl cyclases : similarities and differences to transmembrane adenylyl cyclases.
in Biochimica et Biophysica Acta : Molecular Basis of Disease vol. 1842 (2014) issue 12. - pp. 2535-2547
doi:10.1016/j.bbadis.2014.08.012 ...

Roessler, Claudia; Nowak, Theresa; Pannek, Martin; Gertz, Melanie; Nguyen, Giang Thi Tuyet; Scharfe, Michael; Born, Ilona; Sippl, Wolfgang; Steegborn, Clemens; Schutkowski, Mike
Chemical probing of the human sirtuin 5 active site reveals its substrate acyl specificity and peptide-based inhibitors.
in Angewandte Chemie International Edition vol. 53 (2014) issue 40. - pp. 10728-10732
doi:10.1002/anie.201402679 ...

Kleinbölting, Silke; van den Heuvel, Joop; Steegborn, Clemens
Structural analysis of human soluble adenylyl cyclase and crystal structures of its nucleotide complexes-implications for cyclase catalysis and evolution.
in The FEBS Journal vol. 281 (2014) issue 18. - pp. 4151-4164
doi:10.1111/febs.12913 ...

Schweizer, Ulrich; Schlicker, Christine; Braun, Doreen; Köhrle, Josef; Steegborn, Clemens
Crystal structure of mammalian selenocysteine-dependent iodothyronine deiodinase suggests a peroxiredoxin-like catalytic mechanism.
in Proceedings of the National Academy of Sciences of the United States of America vol. 111 (2014) issue 29. - pp. 10526-10531
doi:10.1073/pnas.1323873111 ...

Suhre, Michael H.; Scheibel, Thomas; Steegborn, Clemens; Gertz, Melanie
Crystallization and preliminary X-ray diffractionanalysis of proximal thread matrix protein 1(PTMP1) from Mytilus galloprovincialis
in Acta Crystallographica Section F vol. 70 (2014) issue 6. - pp. 769-772
doi:10.1107/S2053230X14006165 ...

Kleinbölting, Silke; van den Heuvel, Joop; Kambach, Christian; Weyand, Michael; Leipelt, Martina; Steegborn, Clemens
Expression, purification, crystallization and preliminary X-ray diffraction analysis of a mammalian type 10 adenylyl cyclase.
in Acta Crystallographica Section F vol. 70 (2014) issue 4. - pp. 467-469
doi:10.1107/S2053230X14004014 ...

Kleinbölting, Silke; Diaz, Ana; Moniot, Sébastien; van den Heuvel, Joop; Weyand, Michael; Levin, Lonny R.; Buck, Jochen; Steegborn, Clemens
Crystal structures of human soluble adenylyl cyclase reveal mechanisms of catalysis and of its activation through bicarbonate.
in Proceedings of the National Academy of Sciences of the United States of America vol. 111 (2014) issue 10. - pp. 3727-3732
doi:10.1073/pnas.1322778111 ...

Suhre, Michael H.; Gertz, Melanie; Steegborn, Clemens; Scheibel, Thomas
Structural and functional features of a collagen-binding matrix protein from the mussel byssus
in Nature Communications vol. 5 (2014)
doi:10.1038/ncomms4392 ...

Schutkowski, Mike; Fischer, Frank; Roessler, Claudia; Steegborn, Clemens
New assays and approaches for discovery and design of Sirtuin modulators.
in Expert Opinion on Drug Discovery vol. 9 (2014) issue 2. - pp. 183-199
doi:10.1517/17460441.2014.875526 ...

2013

Nguyen, Giang Thi Tuyet; Gertz, Melanie; Steegborn, Clemens
Crystal structures of Sirt3 complexes with 4'-bromo-resveratrol reveal binding sites and inhibition mechanism.
in Chemistry & Biology vol. 20 (2013) issue 11. - pp. 1375-1385
doi:10.1016/j.chembiol.2013.09.019 ...

Nguyen, Giang Thi Tuyet; Schäfer, Susanne; Gertz, Melanie; Weyand, Michael; Steegborn, Clemens
Structures of human sirtuin 3 complexes with ADP-ribose and with carba-NAD+ and SRT1720: binding details and inhibition mechanism.
in Acta Crystallographica Section D vol. 69 (2013) issue 8. - pp. 1423-1432
doi:10.1107/S0907444913015448 ...

Gertz, Melanie; Fischer, Frank; Nguyen, Giang Thi Tuyet; Lakshminarasimhan, Mahadevan; Schutkowski, Mike; Weyand, Michael; Steegborn, Clemens
Ex-527 inhibits Sirtuins by exploiting their unique NAD+-dependent deacetylation mechanism.
in Proceedings of the National Academy of Sciences of the United States of America vol. 110 (2013) issue 30. - pp. E2772-E2781
doi:10.1073/pnas.1303628110 ...

Laurent, Gaëlle; German, Natalie J.; Saha, Asish K.; de Boer, Vincent C. J.; Davies, Michael; Koves, Timothy R.; Dephoure, Noah; Fischer, Frank; Boanca, Gina; Vaitheesvaran, Bhavapriya; Lovitch, Scott B.; Sharpe, Arlene H.; Kurland, Irwin J.; Steegborn, Clemens; Gygi, Steven P.; Muoio, Deborah M.; Ruderman, Neil B.; Haigis, Marcia C.
SIRT4 coordinates the balance between lipid synthesis and catabolism by repressing malonyl CoA decarboxylase.
in Molecular Cell vol. 50 (2013) issue 5. - pp. 686-698
doi:10.1016/j.molcel.2013.05.012 ...

Moniot, Sébastien; Schutkowski, Mike; Steegborn, Clemens
Crystal structure analysis of human Sirt2 and its ADP-ribose complex.
in Journal of Structural Biology vol. 182 (2013) issue 2. - pp. 136-143

Lakshminarasimhan, Mahadevan; Rauh, David; Schutkowski, Mike; Steegborn, Clemens
Sirt1 activation by resveratrol is substrate sequence-selective.
in Aging vol. 5 (2013) issue 3. - pp. 151-154
http://www.impactaging.com/papers/v5/n3/abs/100542 ...

Suenkel, Benjamin; Fischer, Frank; Steegborn, Clemens
Inhibition of the human deacylase Sirtuin 5 by the indole GW5074.
in Bioorganic & Medicinal Chemistry Letters vol. 23 (2013) issue 1. - pp. 143-146
doi:10.1016/j.bmcl.2012.10.136 ...

Rauh, David; Fischer, Frank; Gertz, Melanie; Lakshminarasimhan, Mahadevan; Bergbrede, Tim; Aladini, Firouzeh; Kambach, Christian; Becker, Christian F. W.; Zerweck, Johannes; Schutkowski, Mike; Steegborn, Clemens
An acetylome peptide microarray reveals specificities and deacetylation substrates for all human sirtuin isoforms.
in Nature Communications vol. 4 (2013) . - pp. 2327
doi:10.1038/ncomms3327 ...

Lakshminarasimhan, Mahadevan; Curth, Ute; Moniot, Sébastien; Mosalaganti, Shyamal; Raunser, Stefan; Steegborn, Clemens
Molecular architecture of the human protein deacetylase Sirt1 and its regulation by AROS and resveratrol.
in Bioscience Reports vol. 33 (2013) issue 3. - pp. 395-404
doi:10.1042/BSR20120121 ...

2012

Middelhaufe, Sabine; Leipelt, Martina; Levin, Lonny R.; Buck, Jochen; Steegborn, Clemens
Identification of a haem domain in human soluble adenylate cyclase.
in Bioscience Reports vol. 32 (2012) issue 5. - pp. 491-499
doi:10.1042/BSR20120051 ...

Topal, Hüsnü; Fulcher, Nanette B.; Bitterman, Jacob; Salazar, Eric; Buck, Jochen; Levin, Lonny R.; Cann, Martin J.; Wolfgang, Matthew C.; Steegborn, Clemens
Crystal structure and regulation mechanisms of the CyaB adenylyl cyclase from the human pathogen Pseudomonas aeruginosa.
in Journal of Molecular Biology vol. 416 (2012) issue 2. - pp. 271-286
doi:10.1016/j.jmb.2011.12.045 ...

Gertz, Melanie; Nguyen, Giang Thi Tuyet; Fischer, Frank; Suenkel, Benjamin; Schlicker, Christine; Fränzel, Benjamin; Tomaschewski, Jana; Aladini, Firouzeh; Becker, Christian F. W.; Wolters, Dirk; Steegborn, Clemens
A molecular mechanism for direct sirtuin activation by resveratrol.
in PLoS One vol. 7 (2012) issue 11. - pp. e49761
doi:10.1371/journal.pone.0049761 ...

Fischer, Frank; Gertz, Melanie; Suenkel, Benjamin; Lakshminarasimhan, Mahadevan; Schutkowski, Mike; Steegborn, Clemens
Sirt5 deacylation activities show differential sensitivities to nicotinamide inhibition.
in PLoS One vol. 7 (2012) issue 9. - pp. e45098
doi:10.1371/journal.pone.0045098 ...

Moniot, Sébastien; Weyand, Michael; Steegborn, Clemens
Structures, substrates, and regulators of Mammalian sirtuins : opportunities and challenges for drug development.
in Frontiers in Pharmacology vol. 3 (2012) issue 16. - pp. 16
doi:10.3389/fphar.2012.00016 ...

2011

Acin-Perez, Rebeca; Russwurm, Michael; Günnewig, Kathrin; Gertz, Melanie; Zoidl, Georg; Ramos, Lavoisier; Buck, Jochen; Levin, Lonny R.; Rassow, Joachim; Manfredi, Giovanni; Steegborn, Clemens
A phosphodiesterase 2A isoform localized to mitochondria regulates respiration.
in The Journal of Biological Chemistry vol. 286 (2011) issue 35. - pp. 30423-30432
doi:10.1074/jbc.M111.266379 ...

Schlicker, Christine; Boanca, Gina; Lakshminarasimhan, Mahadevan; Steegborn, Clemens
Structure-based development of novel sirtuin inhibitors.
in Aging vol. 3 (2011) issue 9. - pp. 852-872
http://www.impactaging.com/papers/v3/n9/full/10038 ...

Russwurm, Michael; Schlicker, Christine; Weyand, Michael; Koesling, Doris; Steegborn, Clemens
Crystal structure of the GAF-B domain from human phosphodiesterase 5.
in Proteins vol. 79 (2011) issue 5. - pp. 1682-1687
doi:10.1002/prot.22989 ...

Lakshminarasimhan, Mahadevan; Steegborn, Clemens
Emerging mitochondrial signaling mechanisms in physiology, aging processes, and as drug targets.
in Experimental Gerontology vol. 46 (2011) issue 2-3. - pp. 174-177
doi:10.1016/j.exger.2010.08.024 ...

2010

Gertz, Melanie; Steegborn, Clemens
The mitochondrial apoptosis pathway and p66Shc : a regulatory redox enzyme or an adapter protein snuggling around?
in Cell Cycle vol. 9 (2010) issue 22. - pp. 4425-4426
doi:10.4161/cc.9.22.14053 ...

Gertz, Melanie; Steegborn, Clemens
The Lifespan-Regulator p66Shc in mitochondria : redox enzyme or redox sensor?
in Antioxidants & Redox Signaling vol. 13 (2010) issue 9. - pp. 1417-1428
doi:10.1089/ars.2010.3147 ...

Baur, Joseph A.; Chen, Danica; Chini, Eduardo N.; Chua, Katrin F.; Cohen, Haim Y.; de Cabo, Rafael; Deng, Chuxia; Dimmeler, Stefanie; Gius, David; Guarente, Leonard P.; Helfand, Stephen L.; Imai, Shin-Ichiro; Itoh, Hiroshi; Kadowaki, Takashi; Koya, Daisuke; Leeuwenburgh, Christiaan; McBurney, Michael; Nabeshima, Yo-Ichi; Neri, Christian; Oberdoerffer, Philipp; Pestell, Richard G.; Rogina, Blanka; Sadoshima, Junichi; Sartorelli, Vittorio; Serrano, Manuel; Sinclair, David A.; Steegborn, Clemens; Tatar, Marc; Tissenbaum, Heidi A.; Tong, Qiang; Tsubota, Kazuo; Vaquero, Alejandro; Verdin, Eric
Dietary restriction : standing up for sirtuins
in Science vol. 329 (2010) issue 5995. - pp. 1012-1013
doi:10.1126/science.329.5995.1012 ...

Gertz, Melanie; Steegborn, Clemens
Function and regulation of the mitochondrial sirtuin isoform Sirt5 in Mammalia.
in Biochimica et Biophysica Acta : Proteins and proteomics vol. 1804 (2010) issue 8. - pp. 1658-1665
doi:10.1016/j.bbapap.2009.09.011 ...

Hall, Rebecca A.; de Sordi, Luisa; Maccallum, Donna M.; Topal, Hüsnü; Eaton, Rebecca; Bloor, James W.; Robinson, Gary K.; Levin, Lonny R.; Buck, Jochen; Wang, Yue; Gow, Neil A .R.; Steegborn, Clemens; Mühlschlegel, Fritz A.
CO(2) acts as a signalling molecule in populations of the fungal pathogen Candida albicans.
in PLoS Pathogens vol. 6 (2010) issue 11. - pp. e1001193
doi:10.1371/journal.ppat.1001193 ...

2009

Innocenti, Alessio; Hall, Rebecca A.; Schlicker, Christine; Scozzafava, Andrea; Steegborn, Clemens; Mühlschlegel, Fritz A.; Supuran, Claudiu T.
Carbonic anhydrase inhibitors : Inhibition and homology modeling studies of the fungal beta-carbonic anhydrase from Candida albicans with sulfonamides.
in Bioorganic & Medicinal Chemistry vol. 17 (2009) issue 13. - pp. 4503-4509
doi:10.1016/j.bmc.2009.05.002 ...

Gertz, Melanie; Fischer, Frank; Leipelt, Martina; Wolters, Dirk; Steegborn, Clemens
Identification of Peroxiredoxin 1 as a novel interaction partner for the lifespan regulator protein p66Shc.
in Aging vol. 1 (2009) issue 2. - pp. 254-265
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC280600 ...

Schlicker, Christine; Hall, Rebecca A.; Vullo, Daniela; Middelhaufe, Sabine; Gertz, Melanie; Supuran, Claudiu T.; Mühlschlegel, Fritz A.; Steegborn, Clemens
Structure and inhibition of the CO2-sensing carbonic anhydrase Can2 from the pathogenic fungus Cryptococcus neoformans.
in Journal of Molecular Biology vol. 385 (2009) issue 4. - pp. 1207-1220
doi:10.1016/j.jmb.2008.11.037 ...

Steegborn, Clemens; Ohndorf, Uta-Maria; Schlicker, Christine
Crystallographic studies on carbonic anhydrases from fungal pathogens for structure-assisted drug development
Supuran, Claudiu T. ; Winum, J.-Y. (Hrsg.): Drug Design of Zinc-Enzyme Inhibitors: Functional, Structural and Disease Applications. - Hoboken, NJ: Wiley, 2009. - pp. 323-334 . - (Wiley Series in Drug Discovery and Development)

2008

Rauch, Annika; Leipelt, Martina; Russwurm, Michael; Steegborn, Clemens
Crystal structure of the guanylyl cyclase Cya2.
in Proceedings of the National Academy of Sciences of the United States of America vol. 105 (2008) issue 41. - pp. 15720-15725
doi:10.1073/pnas.0808473105 ...

Schlicker, Christine; Gertz, Melanie; Papatheodorou, Panagiotis; Kachholz, Barbara; Becker, Christian F. W.; Steegborn, Clemens
Substrates and regulation mechanisms for the human mitochondrial sirtuins Sirt3 and Sirt5.
in Journal of Molecular Biology vol. 382 (2008) issue 3. - pp. 790-801
doi:10.1016/j.jmb.2008.07.048 ...

Innocenti, Alessio; Mühlschlegel, Fritz A.; Hall, Rebecca A.; Steegborn, Clemens; Scozzafava, Andrea; Supuran, Claudiu T.
Carbonic anhydrase inhibitors: inhibition of the beta-class enzymes from the fungal pathogens Candida albicans and Cryptococcus neoformans with simple anions.
in Bioorganic & Medicinal Chemistry Letters vol. 18 (2008) issue 18. - pp. 5066-5070
doi:10.1016/j.bmcl.2008.07.122 ...

Tammenkoski, Marko; Koivula, Katja; Cusanelli, Emilio; Zollo, Massimo; Steegborn, Clemens; Baykov, Alexander A.; Lahti, Reijo
Human metastasis regulator protein H-prune is a short-chain exopolyphosphatase.
in Biochemistry vol. 47 (2008) issue 36. - pp. 9707-9713
doi:10.1021/bi8010847 ...

Schlicker, Christine; Rauch, Annika; Hess, Ken C.; Kachholz, Barbara; Levin, Lonny R.; Buck, Jochen; Steegborn, Clemens
Structure-based development of novel adenylyl cyclase inhibitors.
in Journal of Medicinal Chemistry vol. 51 (2008) issue 15. - pp. 4456-4464
doi:10.1021/jm800481q ...

Gertz, Melanie; Fischer, Frank; Wolters, Dirk; Steegborn, Clemens
Activation of the lifespan regulator p66Shc through reversible disulfide bond formation.
in Proceedings of the National Academy of Sciences of the United States of America vol. 105 (2008) issue 15. - pp. 5705-5709
doi:10.1073/pnas.0800691105 ...

Garzia, Livia; D'Angelo, A.; Amoresano, A.; Knauer, Shirley K.; Cirulli, C.; Campanella, C.; Stauber, R. H.; Steegborn, Clemens; Iolascon, A.; Zollo, Massimo
Phosphorylation of nm23-H1 by CKI induces its complex formation with h-prune and promotes cell motility
in Oncogene vol. 27 (2008) issue 13. - pp. 1853-1864
doi:10.1038/sj.onc.1210822 ...

2007

Middelhaufe, Sabine; Garzia, Livia; Ohndorf, Uta-Maria; Kachholz, Barbara; Zollo, Massimo; Steegborn, Clemens
Domain mapping on the human metastasis regulator protein h-Prune reveals a C-terminal dimerization domain.
in Biochemical Journal vol. 407 (2007) issue 2. - pp. 199-205
doi:10.1042/BJ20070408 ...

Mannherz, Hans Georg; Ballweber, Edda; Galla, Marco; Villard, Sylvie; Granier, Claude; Steegborn, Clemens; Schmidtmann, Anja; Jaquet, Kornelia; Pope, Brian; Weeds, Alan G.
Mapping the ADF/cofilin binding site on monomeric actin by competitive cross-linking and peptide array : evidence for a second binding site on monomeric actin.
in Journal of Molecular Biology vol. 366 (2007) issue 3. - pp. 745-755
doi:10.1016/j.jmb.2006.11.100 ...

2006

Kamenetsky, Margarita; Middelhaufe, Sabine; Bank, Erin M.; Levin, Lonny R.; Buck, Jochen; Steegborn, Clemens
Molecular details of cAMP generation in mammalian cells : a tale of two systems.
in Journal of Molecular Biology vol. 362 (2006) issue 4. - pp. 623-639
doi:10.1016/j.jmb.2006.07.045 ...

Mogensen, Estelle Geweiss; Janbon, Guilhem; Chaloupka, James; Steegborn, Clemens; Fu, Man Shun; Moyrand, Frédérique; Klengel, Torsten; Pearson, David S.; Geeves, Michael A.; Buck, Jochen; Levin, Lonny R.; Mühlschlegel, Fritz A.
Cryptococcus neoformans senses CO2 through the carbonic anhydrase Can2 and the adenylyl cyclase Cac1.
in Eukaryotic Cell vol. 5 (2006) issue 1. - pp. 103-111
doi:10.1128/EC.5.1.103-111.2006 ...

2005

Steegborn, Clemens; Litvin, Tatiana N.; Hess, Kenneth C.; Capper, Austin B.; Taussig, Ronald; Buck, Jochen; Levin, Lonny R.; Wu, Hao
A novel mechanism for adenylyl cyclase inhibition from the crystal structure of its complex with catechol estrogen.
in The Journal of Biological Chemistry vol. 280 (2005) issue 36. - pp. 31754-31759
doi:10.1074/jbc.M507144200 ...

Steegborn, Clemens; Litvin, Tatiana N.; Levin, Lonny R.; Buck, Jochen; Wu, Hao
Bicarbonate activation of adenylyl cyclase via promotion of catalytic active site closure and metal recruitment.
in Nature Structural & Molecular Biology vol. 12 (2005) issue 1. - pp. 32-37
doi:10.1038/nsmb880 ...

2004

Ye, Hong; Chen, Tzu-Chao; Xu, Xiaohui; Pennycooke, Micha; Wu, Hao; Steegborn, Clemens
Crystal structure of the putative adapter protein MTH1859.
in Journal of Structural Biology vol. 148 (2004) issue 2. - pp. 251-256
doi:10.1016/j.jsb.2004.06.004 ...

2003

Augustin, Martin A.; Reichert, Andreas S.; Betat, Heike; Huber, Robert; Mörl, Mario; Steegborn, Clemens
Crystal structure of the human CCA-adding enzyme: insights into template-independent polymerization.
in Journal of Molecular Biology vol. 328 (2003) issue 5. - pp. 985-994
doi:10.1016/S0022-2836(03)00381-4 ...

Messerschmidt, Albrecht; Worbs, Michael; Steegborn, Clemens; Wahl, Markus C.; Huber, Robert; Laber, Bernd; Clausen, Tim
Determinants of enzymatic specificity in the Cys-Met-metabolism PLP-dependent enzymes family: crystal structure of cystathionine gamma-lyase from yeast and intrafamiliar structure comparison.
in Biological Chemistry vol. 384 (2003) issue 3. - pp. 373-386
doi:10.1515/BC.2003.043 ...

Xu, Guozhou; Rich, Rebecca L.; Steegborn, Clemens; Min, Tongpil; Huang, Yihua; Myszka, David G.; Wu, Hao
Mutational analyses of the p35-caspase interaction. A bowstring kinetic model of caspase inhibition by p35.
in The Journal of Biological Chemistry vol. 278 (2003) issue 7. - pp. 5455-5461
doi:10.1074/jbc.M211607200 ...

2002

Stabler, Sally P.; Steegborn, Clemens; Wahl, Markus C.; Oliveriusova, Jana; Kraus, Jan P.; Allen, Robert H.; Wagner, Conrad; Mudd, S. Harvey
Elevated plasma total homocysteine in severe methionine adenosyltransferase I/III deficiency.
in Metabolism vol. 51 (2002) issue 8. - pp. 981-988
doi:10.1053/meta.2002.34017 ...

Rossoll, Wilfried; Kröning, Ann-Kathrin; Ohndorf, Uta-Maria; Steegborn, Clemens; Jablonka, Sibylle; Sendtner, Michael
Specific interaction of Smn, the spinal muscular atrophy determining gene product, with hnRNP-R and gry-rbp/hnRNP-Q: a role for Smn in RNA processing in motor axons?
in Human Molecular Genetics vol. 11 (2002) issue 1. - pp. 93-105
doi:10.1093/hmg/11.1.93 ...

2001

Steegborn, Clemens; Danot, Olivier; Huber, Robert; Clausen, Tim
Crystal structure of transcription factor MalT domain III: a novel helix repeat fold implicated in regulated oligomerization.
in Structure vol. 9 (2001) issue 11. - pp. 1051-1060
doi:10.1016/S0969-2126(01)00665-7 ...

Steegborn, Clemens; Laber, Bernd; Messerschmidt, Albrecht; Huber, Robert; Clausen, Tim
Crystal structures of cystathionine gamma-synthase inhibitor complexes rationalize the increased affinity of a novel inhibitor.
in Journal of Molecular Biology vol. 311 (2001) issue 4. - pp. 789-801
doi:10.1006/jmbi.2001.4880 ...

Ohndorf, Uta-Maria; Steegborn, Clemens; Knijff, Rainer; Sondermann, Peter
Contributions of the individual domains in human La protein to its RNA 3'-end binding activity.
in The Journal of Biological Chemistry vol. 276 (2001) issue 29. - pp. 27188-27196
doi:10.1074/jbc.M102891200 ...

Dorowski, Anja; Hofmann, Andreas; Steegborn, Clemens; Boicu, Marius; Huber, Robert
Crystal structure of paprika ferredoxin-NADP+ reductase. Implications for the electron transfer pathway.
in The Journal of Biological Chemistry vol. 276 (2001) issue 12. - pp. 9253-9263
doi:10.1074/jbc.M004576200 ...

2000

Steegborn, Clemens; Schneider-Hassloff, Henriette; Zeeb, Markus; Balbach, Jochen
Cooperativity of a protein folding reaction probed at multiple chain positions by real-time 2D NMR spectroscopy.
in Biochemistry vol. 39 (2000) issue 27. - pp. 7910-7919
doi:10.1021/bi000270u ...

Clausen, Tim; Kaiser, Jens T.; Steegborn, Clemens; Huber, Robert; Kessler, Dorothea
Crystal structure of the cystine C-S lyase from Synechocystis: stabilization of cysteine persulfide for FeS cluster biosynthesis.
in Proceedings of the National Academy of Sciences of the United States of America vol. 97 (2000) issue 8. - pp. 3856-3861
doi:10.1073/pnas.97.8.3856 ...

Clausen, Tim; Schlegel, Anja; Peist, Ralf; Schneider, Eva; Steegborn, Clemens; Chang, Yuh-Shin; Haase, Andrea; Bourenkov, Gleb P.; Bartunik, Hans D.; Boos, Winfried
X-ray structure of MalY from Escherichia coli: a pyridoxal 5'-phosphate-dependent enzyme acting as a modulator in mal gene expression.
in The EMBO Journal vol. 19 (2000) issue 5. - pp. 831-842
doi:10.1093/emboj/19.5.831 ...

Schreiber, Valerie; Steegborn, Clemens; Clausen, Tim; Boos, Winfried; Richet, Evelyne
A new mechanism for the control of a prokaryotic transcriptional regulator: antagonistic binding of positive and negative effectors.
in Molecular microbiology vol. 35 (2000) issue 4. - pp. 765-776
doi:10.1046/j.1365-2958.2000.01747.x ...

1999

Clausen, Tim; Wahl, Markus C.; Messerschmidt, Albrecht; Huber, Robert; Fuhrmann, Jens C.; Laber, Bernd; Streber, Wolfgang; Steegborn, Clemens
Cloning, purification and characterisation of cystathionine gamma-synthase from Nicotiana tabacum.
in Biological Chemistry vol. 380 (1999) issue 10. - pp. 1237-1242
doi:10.1515/BC.1999.157 ...

Steegborn, Clemens; Messerschmidt, Albrecht; Laber, Bernd; Streber, Wolfgang; Huber, Robert; Clausen, Tim
The crystal structure of cystathionine gamma-synthase from Nicotiana tabacum reveals its substrate and reaction specificity.
in Journal of Molecular Biology vol. 290 (1999) issue 5. - pp. 983-996
doi:10.1006/jmbi.1999.2935 ...

Steegborn, Clemens; Clausen, Tim; Sondermann, Peter; Jacob, Uwe; Worbs, Michael; Marinkovic, Snezan; Huber, Robert; Wahl, Markus C.
Kinetics and inhibition of recombinant human cystathionine gamma-lyase. Toward the rational control of transsulfuration.
in The Journal of Biological Chemistry vol. 274 (1999) issue 18. - pp. 12675-12684
doi:10.1074/jbc.274.18.12675 ...

Balbach, Jochen; Steegborn, Clemens; Schindler, Thomas; Schmid, Franz X.
A protein folding intermediate of ribonuclease T1 characterized at high resolution by 1D and 2D real-time NMR spectroscopy.
in Journal of Molecular Biology vol. 285 (1999) issue 2. - pp. 829-842
doi:10.1006/jmbi.1998.2364 ...

1997

Steegborn, Clemens; Skládal, Petr
Construction and characterization of the direct piezoelectric immunosensor for atrazine operating in solution.
in Biosensors and Bioelectronics vol. 12 (1997) issue 1. - pp. 19-27
doi:10.1016/0956-5663(96)89086-5 ...

1996

Metzger, Armin U.; Schindler, Thomas; Willbold, Dieter; Kraft, Margot; Steegborn, Clemens; Volkmann, Andrea; Frank, Rainer W.; Rösch, Paul
Structural rearrangements on HIV-1 Tat (32-72) TAR complex formation.
in FEBS Letters vol. 384 (1996) issue 3. - pp. 255-259
doi:10.1016/0014-5793(96)00314-6 ...

Sprinzl, Mathias; Steegborn, Clemens; Hübel, Frank; Steinberg, Sergey
Compilation of tRNA sequences and sequences of tRNA genes.
in Nucleic Acids Research vol. 24 (1996) issue 1. - pp. 68-72
doi:10.1093/nar/24.1.68 ...

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