Signaling mechanisms in aging and disease – from proteins to targets to drugs
Many molecular details of aging, as a fundamental process in life, and of aging-associated diseases are still poorly understood. We study mechanistic details of function, regulation, and pharmacological modulation of metabolic sensor proteins, which have been found to play key roles in regular metabolism but also in aging processes and the pathophysiology of aging-related diseases. We study these proteins and their interactions using structural and biochemical techniques, and we aim to develop small molecule modulators for these systems as chemical tools and as lead compounds for drug development.
- Sirtuins, NAD+-dependent signaling and protein (de)acetylation & (de)acylation
- cAMP & cGMP signaling
- Redox signaling and redox signaling enzymes
Research Group Prof. Steegborn